2. Metabolic Disease

Metabolic Disease

Metabolic Disease

Related Products

PDF 53.7 MB

Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-14806A
    Teneligliptin hydrobromide 906093-29-6 ≥99.0%
    Teneligliptin (MP-513) hydrobromide is an orally active and selective dipeptidyl peptidase 4 (DPP-4) inhibitor (IC50s: 0.37 and 0.29 nM for the human and rat DPP-4, respectively). Teneligliptin hydrobromide improves blood glucose levels and can be used in researches related to type 2 diabetes mellitus.
    Teneligliptin hydrobromide
  • HY-12425
    DGAT1-IN-1 1449779-49-0 ≥98.0%
    DGAT1-IN-1 is a potent DGAT1 inhibitor with IC50 of < 10 nM(cell lysate from Hep3B cells overexpressing human DGAT1).
    DGAT1-IN-1
  • HY-139588
    Vemircopan 2086178-00-7 98.61%
    Vemircopan (ALXN2050) is an orally active complement factor D (FD) inhibitor. Vemircopan can be used in the research of diseases such as myasthenia gravis, lupus nephritis, IgA nephropathy, and paroxysmal nocturnal hemoglobinuria.
    Vemircopan
  • HY-101499A
    GKT136901 hydrochloride 1254507-01-1 99.90%
    GKT136901 hydrochloride is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 hydrochloride is also a selective and direct scavenger of peroxynitrite. GKT136901 hydrochloride can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 hydrochloride also has anti-inflammatory activity.
    GKT136901 hydrochloride
  • HY-B0143S2
    Niacin-d4 66148-15-0 99.15%
    Niacin-d4 is the deuterium labeled Niacin. Niacin (Nicotinic acid) is a vitamin and is part of the vitamin B group.
    Niacin-d4
  • HY-12699
    RO5166017 1048346-74-2 99.48%
    RO5166017 is an orally active and species-crosses TAAR1 agonist, with Ki values of 1.9 nM, 2.7 nM, 31 nM and 24 nM for mouse, rat, human and cynomolgus monkey, respectively.
    RO5166017
  • HY-15564
    AR 231453 733750-99-7 99.70%
    AR 231453 is a potent, specific and orally available GPR119 agonist. AR 231453 can stimulate β-cell replication and improve islet graft function s.
    AR 231453
  • HY-B0025
    Voglibose 83480-29-9 ≥98.0%
    Voglibose is an orally active alpha-glucosidase inhibitor that prevents the development of colorectal precancerous lesions induced by obesity and diabetes. Voglibose reduces oxidative stress in an inflammatory environment and inhibits the insulin-like growth factor/insulin-like growth factor-1 receptor (IGF/IGF-1R) functional axis.
    Voglibose
  • HY-B1278
    D-α-Tocopherol acetate 58-95-7 ≥98.0%
    D-α-Tocopherol acetate (D-Vitamin E acetate) can be hydrolyzed to d-alpha-tocopherol (VE) and absorbed in the small intestine.
    D-α-Tocopherol acetate
  • HY-N0341
    Scopolin 531-44-2 ≥99.0%
    Scopolin is a coumarin isolated from Arabidopsis thaliana (Arabidopsis) roots. Scopolin attenuated hepatic steatosis through activation of SIRT1-mediated signaling cascades.
    Scopolin
  • HY-N0661
    Alliin 556-27-4 99.72%
    Alliin, an orally active sulfoxide compound that can be isolated from garlic, exhibits hypoglycemic, antioxidant, anti-inflammatory and antitumor activities.
    Alliin
  • HY-N1984
    Artemisic acid 80286-58-4 99.74%
    Artemisinic acid (Qing Hao acid), an amorphane sesquiterpene isolated from Artemisia annua L., possesses a variety of pharmacological activity, such as antimalarial activity, anti-tumor activity, antipyretic effect, antibacterial activity, allelopathy effect and anti-adipogenesis effect.
    Artemisic acid
  • HY-N2025
    Oroxin A 57396-78-8 99.76%
    Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE). Oroxin A acts as a partial PPARγ agonist that can activate PPARγ transcriptional activation. Oroxin A activates PPARγ by docking into the PPARγ protein ligand-binding domain. Oroxin A also exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity. Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence.
    Oroxin A
  • HY-N2447
    Amarogentin 21018-84-8 99.93%
    Amarogentin is a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots. Amarogentin exhibits many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin exerts hepatoprotective and immunomodulatory effects. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways. Amarogentin exerts beneficial vasculo-metabolic effect by activating AMPK.
    Amarogentin
  • HY-N3002
    α-Arbutin 84380-01-8 99.98%
    α-Arbutin (4-Hydroxyphenyl α-D-glucopyranoside) is a tyrosinase inhibitor, which is used as an effective skin whiteners. α-Arbutin is promising for research of various diseases such as hyperpigmentation disorders, types of cancers, central nervous system disorders, osteoporosis, diabetes.
    α-Arbutin
  • HY-N7091
    Atrazine 1912-24-9 99.26%
    Atrazine, a triazine herbicide, is principally used for control of certain annual broadleaf and grass weeds. Atrazine inhibits photophosphorylation but typically does not result in lethality or permanent cell damage in the short term.
    Atrazine
  • HY-P0196
    Cholecystokinin Octapeptide, desulfated 25679-24-7 99.54%
    Cholecystokinin Octapeptide, desulfated is a synthetic desulfated octapeptides of cholecystokinin (CCK).
    Cholecystokinin Octapeptide, desulfated
  • HY-P3204
    POT-4 934461-40-2 99.64%
    POT-4 (AL-78898A), a Compstatin derivative, is a potent inhibitor of complement factor C3 activation. POT-4 can be used for age-related macular degeneration research
    POT-4
  • HY-Y0136
    3-Indoleacetonitrile 771-51-7 ≥98.0%
    3-Indoleacetonitrile is an endogenous metabolite.
    3-Indoleacetonitrile
  • HY-Y1031
    3-Ethoxy-3-oxopropanoic acid 1071-46-1 ≥98.0%
    3-Ethoxy-3-oxopropanoic acid is an endogenous metabolite. 3-Ethoxy-3-oxopropanoic acid promotes plant growth.
    3-Ethoxy-3-oxopropanoic acid
Cat. No. Product Name / Synonyms Application Reactivity